From Lynn Davidson at Newsbusters:

According to the former Air America radio host, a conservative starts out an “asshole,” and the politics come later. She asserted, “The reason a person is a conservative republican (sic) is because something is wrong with them…It really is neuroscience.”

In this February 12 interview with the environmentalist celebrity blog Ecorazzi, Garofalo also claimed the “irrational” emotion center of the brain, the limbic system, is what creates conservatives (text reformatted, profanity edited, all bold mine):

The reason a person is a conservative republican is because something is wrong with them. Again, that’s science – that’s neuroscience. You cannot be well adjusted, open-minded, pluralistic, enlightened and be a republican. It’s counter-intuitive. And they revel in their anti-intellectualism. They revel in their cruelty.

I don’t know if you heard me talking to Jenny a while ago, but I was saying that first you have to be an asshole and then comes the conservatism. You gotta be a dick to cleave onto their ideology…

Sarah Palin didn’t escape Garofalo’s ire either. She said Palin is “small-minded and mean-spirited” and “is what the Republican Party has become: obstructionist, contrarians, small-minded, all of these things (sic).”